服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.
作者信息
Boullin D J, Woods H F, Grimes R P, Grahame-Smith D G
出版信息
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.
Abstract
1 The aggregation response of platelets induced by 5-HT was greatly increased in psychiatric patients receiving chlorpromazine therapy when compared with normal volunteers and psychiatric patients not receiving chlorpromazine. 2 Platelet aggregation responses to ADP were normal during chlorpromazine therapy, but 5-HT induced aggregation was increased in rate and the typical transient reversible response was converted to an irreversible response in all subjects. This was usually indistinguishable from the ADP response. 3 When chlorpromazine therapy was stopped, plasma concentrations of chlorpromazine, monodesmethylchlorpromazine and chlorpromazine sulphoxide fell rapidly within one week, whereas 5-HT induced platelet aggregation responses became normal after three weeks. The enhanced responses returned when chlorpromazine therapy was re-instituted. 4 It is possible that platelet aggregation responses to 5-HT in vitro could prove to be a useful index of the pharmacological effect of chlorpromazine in vivo.
摘要
- 与正常志愿者以及未接受氯丙嗪治疗的精神科患者相比，接受氯丙嗪治疗的精神科患者中，5-羟色胺诱导的血小板聚集反应显著增强。2. 在氯丙嗪治疗期间，血小板对二磷酸腺苷（ADP）的聚集反应正常，但5-羟色胺诱导的聚集反应速率增加，并且在所有受试者中，典型的短暂可逆反应转变为不可逆反应。这通常与ADP反应无法区分。3. 停止氯丙嗪治疗后，氯丙嗪、去甲氯丙嗪和氯丙嗪亚砜的血浆浓度在一周内迅速下降，而5-羟色胺诱导的血小板聚集反应在三周后恢复正常。重新开始氯丙嗪治疗时，增强的反应又会出现。4. 体外血小板对5-羟色胺的聚集反应可能被证明是氯丙嗪体内药理作用的一个有用指标。
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