氯丙嗪对血小板中血清素摄取的影响。

Effects of chlorpromazine on serotonin uptake in blood platelets.

作者信息

Arora R C, Meltzer H Y

出版信息

Psychiatry Res. 1983 May;9(1):23-8. doi: 10.1016/0165-1781(83)90085-9.

Abstract

Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 microM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 +/- 0.1 microM) in a competitive manner.

摘要

对精神分裂症患者在接受氯丙嗪（CPZ）治疗2 - 3周前后的血小板5 - 羟色胺（5 - HT）摄取情况进行了研究。未用药的精神分裂症患者与正常对照者在5 - HT的亲和力（Km）或5 - HT摄取的最大速度（Vmax）方面未发现差异。给予CPZ后，Km和Vmax显著增加。在大多数受试者中，0.5微摩尔浓度下5 - HT的特异性摄取显著降低。氯丙嗪在体外以竞争性方式抑制正常对照者血小板对5 - HT的摄取（IC50，1.8±0.1微摩尔）。