Smiałowska M, Gastoł-Lewińska L, Tokarski K
Laboratory of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Neuropeptides. 1994 Apr;26(4):225-32. doi: 10.1016/0143-4179(94)90074-4.
The role of noradrenergic alpha-1 receptors in increasing the behavioural activity after neuropeptide Y (NPY) injection into the frontal cortex was examined in rats. NPY (1 micrograms/1 microliter) injected into the frontal cortex of rats with chronically implanted cannulae, increased their locomotor and exploratory activity in the open field test. Similar effects were observed after injection of the alpha-1-adrenergic agonist phenylephrine (PH) (3-19 micrograms/1 microliter). Behavioural stimulation after NPY or PH was totally abolished by pretreatment with benextramine (1.73-173 micrograms/1 microliter), a compound blocking NPY and alpha-adrenergic receptors. The NPY-induced activation of behaviour was also abolished by i.p. injection of prazosine (3 mg/kg), a specific alpha-1-adrenergic receptor antagonist. It is concluded that: 1) NPY injected into the rat frontal cortex induces an increase in the locomotor and exploratory activity of the animals; and 2) indirect activation of alpha-1-adrenergic receptor seems to play a crucial role in the observed behavioural effects.
研究了去甲肾上腺素能α-1受体在向大鼠额叶皮质注射神经肽Y（NPY）后增加行为活动中的作用。向长期植入套管的大鼠额叶皮质注射NPY（1微克/1微升），在旷场试验中增加了它们的运动和探索活动。注射α-1肾上腺素能激动剂去氧肾上腺素（PH）（3 - 19微克/1微升）后也观察到类似效果。用贝那替秦（1.73 - 173微克/1微升）预处理可完全消除NPY或PH后的行为刺激，贝那替秦是一种阻断NPY和α-肾上腺素能受体的化合物。腹腔注射哌唑嗪（3毫克/千克），一种特异性α-1肾上腺素能受体拮抗剂，也可消除NPY诱导的行为激活。得出以下结论：1）向大鼠额叶皮质注射NPY可诱导动物运动和探索活动增加；2）α-1肾上腺素能受体的间接激活似乎在观察到的行为效应中起关键作用。
