Role of dopaminergic mechanisms in the regulation of stress responses in experimental animals.

The effects of some dopaminergic agents were evaluated on stress responses in normal and immunized experimental animals. Restraint stress (RS) consistently induced gastric mucosal lesions and elevated plasma corticosterone in rats. Pretreatment with alpha-methyltyrosine (alpha-MT), haloperidol, or sulpiride aggravated both responses, whereas bromocriptine attenuated them. In rats immunized with sheep red blood cells (SRBCs), RS prevented the booster-induced rise in anti-SRBC antibody titre. This response was further suppressed by alpha-MT, haloperidol, or sulpiride pretreatment, whereas bromocriptine potentiated the humoral immune response. In mice immunized with SRBCs, antigen challenge-induced increase in footpad thickness was inhibited by RS. Similar inhibitions in this response were also seen after alpha-MT or haloperidol treatment. The results are discussed in light of complex dopaminergic mechanisms in the regulation of visceral, endocrinological, and immune responses during stress.