Puri S, Ray A, Chakravarti A K, Sen P
Department of Pharmacology, University College of Medical Sciences, Shahdara, Delhi, India.
Pharmacol Biochem Behav. 1994 May;48(1):53-6. doi: 10.1016/0091-3057(94)90497-9.
The effects of some dopaminergic agents were evaluated on stress responses in normal and immunized experimental animals. Restraint stress (RS) consistently induced gastric mucosal lesions and elevated plasma corticosterone in rats. Pretreatment with alpha-methyltyrosine (alpha-MT), haloperidol, or sulpiride aggravated both responses, whereas bromocriptine attenuated them. In rats immunized with sheep red blood cells (SRBCs), RS prevented the booster-induced rise in anti-SRBC antibody titre. This response was further suppressed by alpha-MT, haloperidol, or sulpiride pretreatment, whereas bromocriptine potentiated the humoral immune response. In mice immunized with SRBCs, antigen challenge-induced increase in footpad thickness was inhibited by RS. Similar inhibitions in this response were also seen after alpha-MT or haloperidol treatment. The results are discussed in light of complex dopaminergic mechanisms in the regulation of visceral, endocrinological, and immune responses during stress.
研究评估了一些多巴胺能药物对正常和免疫实验动物应激反应的影响。束缚应激（RS）持续诱导大鼠胃黏膜损伤并使血浆皮质酮升高。用α-甲基酪氨酸（α-MT）、氟哌啶醇或舒必利预处理会加重这两种反应，而溴隐亭则会减轻它们。在用绵羊红细胞（SRBC）免疫的大鼠中，RS阻止了加强免疫诱导的抗SRBC抗体滴度升高。这种反应在α-MT、氟哌啶醇或舒必利预处理后进一步受到抑制，而溴隐亭则增强了体液免疫反应。在用SRBC免疫的小鼠中，抗原激发诱导的足垫厚度增加受到RS的抑制。在α-MT或氟哌啶醇治疗后，该反应也出现类似的抑制。根据应激期间调节内脏、内分泌和免疫反应的复杂多巴胺能机制对结果进行了讨论。
