Cao L, Qian P D, Jing L J, Liang Q J, Zhao Z Z
Pediatric Department, Hebei Provincial Hospital, Shijiazhuang.
Chin Med J (Engl). 1993 Oct;106(10):783-7.
Perinatal asphyxia is one of the major causes of cerebral injury in neonates. It may be due to the increased endogenous opioid-like substances (OLS) in the body. The levels of three OLS, namely leucine-enkephalin (LEK), beta-endorphin (beta-EP) and dynorphin A1-13 (DynoA1-13) of 44 cases with neonatal asphyxia were studied by radioimmunoassay. The OLS level in plasma and cerebral spinal fluid (CSF) were higher in asphyxiated group than those in the control group, especially in asphyxiated cases with fetal distress. The OLS levels of CSF were also higher in cases with cerebral injury than in those without cerebral injury, while the levels of OLS in plasma had no difference in these two groups. The relationship between OLS levels and asphyxia and cerebral injury is also discussed.
围产期窒息是新生儿脑损伤的主要原因之一。这可能是由于体内内源性阿片样物质（OLS）增加所致。采用放射免疫分析法研究了44例新生儿窒息患儿的三种OLS，即亮氨酸脑啡肽（LEK）、β-内啡肽（β-EP）和强啡肽A1-13（DynoA1-13）的水平。窒息组血浆和脑脊液（CSF）中的OLS水平高于对照组，尤其是伴有胎儿窘迫的窒息病例。脑损伤患儿脑脊液中的OLS水平也高于无脑损伤患儿，而两组血浆中的OLS水平无差异。还讨论了OLS水平与窒息和脑损伤之间的关系。
