Xu Y J
Hospital 309th of people's Liberation Army Beijing.
Zhonghua Wai Ke Za Zhi. 1993 Oct;31(10):628-9.
An immunohistochemical study of thyroid carcinoma using PC10, a monoclonal antibody against proliferating cell nuclear antigen (PCNA/Cyclin), was performed on paraffin sections. There was significant difference statistically in PCNA index between any two types of all four types of thyroid carcinoma (P < 0.01), with the index of 35.36 +/- 9.59 in papillary carcinoma, 184.60 +/- 7.08 in follicular carcinoma, 392.43 +/- 31.66 in medullary carcinoma, and 488.28 +/- 19.93 in undifferentiated carcinoma. The results indicate that PCNA/Cyclin detection is a reliable method to examine the fraction of proliferating cells of thyroid carcinoma on paraffin sections, and it could be used to determine the prognosis of thyroid carcinoma.
利用抗增殖细胞核抗原（PCNA/细胞周期蛋白）的单克隆抗体PC10，对石蜡切片进行甲状腺癌的免疫组织化学研究。在所有四种类型的甲状腺癌中，任意两种类型之间的PCNA指数在统计学上均存在显著差异（P < 0.01），其中乳头状癌的指数为35.36 +/- 9.59，滤泡状癌为184.60 +/- 7.08，髓样癌为392.43 +/- 31.66，未分化癌为488.28 +/- 19.93。结果表明，PCNA/细胞周期蛋白检测是一种可靠的方法，可用于检测石蜡切片上甲状腺癌细胞的增殖分数，并可用于判断甲状腺癌的预后。
