甲状腺髓样癌中的增殖细胞核抗原（PCNA）
Proliferating cell nuclear antigen (PCNA) in medullary thyroid carcinoma.
作者信息
Skopelitou A, Korkolopoulou P, Papanikolaou A, Hadjiyannakis M
机构信息
Pathology Department, Asklepeion Hospital, Voula Attikis, Greece.
出版信息
J Cancer Res Clin Oncol. 1993;119(7):379-81. doi: 10.1007/BF01218417.
Abstract
We investigated the expression of proliferating cell nuclear antigen (PCNA) in paraffin sections from 20 cases of medullary thyroid carcinoma (MTC). Follow-up data were available in eleven cases. PCNA index positively correlated with the degree of cellular pleomorphism (grade) of the tumor (p < 0.01), the pathologic stage (p < 0.01) and the poor clinical outcome (p < 0.05). These findings suggest that PCNA may be of prognostic significance in MTC.
摘要
我们研究了20例甲状腺髓样癌（MTC）石蜡切片中增殖细胞核抗原（PCNA）的表达情况。11例患者有随访数据。PCNA指数与肿瘤的细胞多形性程度（分级）（p < 0.01）、病理分期（p < 0.01）及不良临床结局（p < 0.05）呈正相关。这些发现提示PCNA在MTC中可能具有预后意义。
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本文引用的文献
1
Medullary carcinoma of the thyroid in the multiple endocrine neoplasia IIA syndrome.多发性内分泌腺瘤病IIA综合征中的甲状腺髓样癌。
Am J Surg Pathol. 1981 Jul;5(5):459-72. doi: 10.1097/00000478-198107000-00005.
2
The prognostic value of calcitonin immunostaining in medullary carcinoma of the thyroid.
J Clin Endocrinol Metab. 1984 Nov;59(5):850-6. doi: 10.1210/jcem-59-5-850.
3
The significance of mitotic rate: a retrospective study of 127 thyroid carcinomas.有丝分裂率的意义：127例甲状腺癌的回顾性研究
Hum Pathol. 1985 Oct;16(10):1042-6. doi: 10.1016/s0046-8177(85)80282-3.
4
Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.培养细胞中核蛋白细胞周期蛋白增殖细胞核抗原分布的细胞周期依赖性变化：S期的细分
Proc Natl Acad Sci U S A. 1985 May;82(10):3262-6. doi: 10.1073/pnas.82.10.3262.
5
Prognostic factors in medullary thyroid carcinomas. Survival in relation to age, sex, stage, histology, immunocytochemistry, and DNA content.甲状腺髓样癌的预后因素。生存与年龄、性别、分期、组织学、免疫细胞化学及DNA含量的关系。
Cancer. 1988 Feb 15;61(4):806-16. doi: 10.1002/1097-0142(19880215)61:4<806::aid-cncr2820610428>3.0.co;2-g.
6
Medullary thyroid cancer. An immunohistochemical and humoral study using six separate antigens.甲状腺髓样癌。一项使用六种不同抗原的免疫组织化学和体液研究。
Am J Clin Pathol. 1991 Mar;95(3):300-8. doi: 10.1093/ajcp/95.3.300.
7
Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms.石蜡切片中增殖细胞核抗原（PCNA）的免疫定位：一种细胞增殖指标，在某些肿瘤中存在表达失调的证据。
J Pathol. 1990 Dec;162(4):285-94. doi: 10.1002/path.1711620403.
8
The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis.
Histopathology. 1991 Jul;19(1):21-7. doi: 10.1111/j.1365-2559.1991.tb00890.x.
9
Prognostic value of proliferating cell nuclear antigen in gastric carcinoma.增殖细胞核抗原在胃癌中的预后价值
J Clin Pathol. 1991 Aug;44(8):655-9. doi: 10.1136/jcp.44.8.655.
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