Urbanek R W, Cohen D J
Department of Medicine, Staten Island University Hospital, NY 10305.
J Am Acad Dermatol. 1994 Aug;31(2 Pt 2):390-2. doi: 10.1016/s0190-9622(94)70179-2.
We describe the worsening of porphyria cutanea tarda in a young woman while she was taking oral contraceptives. However, she did not have an exacerbation during two pregnancies. We conclude that estrogens produced during pregnancy do not exert the same effect as orally administered medications that contain estrogen. The pronounced effect of oral ethinyl estradiol on the liver may be attributed to its first-pass effect on that organ.
我们描述了一名年轻女性在服用口服避孕药期间迟发性皮肤卟啉病病情恶化的情况。然而，她在两次怀孕期间病情并未加重。我们得出结论，怀孕期间产生的雌激素与口服含雌激素药物的作用不同。口服炔雌醇对肝脏的显著作用可能归因于其对该器官的首过效应。
