Hatfield T, Gallagher M
Department of Psychology, University of North Carolina, Chapel Hill 27599-3270, USA.
Behav Neurosci. 1995 Aug;109(4):663-8. doi: 10.1037//0735-7044.109.4.663.
Two experiments examined the effects of infusing an N-methyl-D-aspartate (NMDA) receptor antagonist, d-2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.
两项实验研究了注入N-甲基-D-天冬氨酸（NMDA）受体拮抗剂D-2-氨基-5-磷酸戊酸（D-APV）对味觉增强气味条件反射的影响：这是一种依赖于两种感觉模态信息处理的学习形式。在实验1中，注入D-APV的大鼠在获取对气味线索的增强学习方面受损。药物治疗后，这种学习的表达以及简单味觉厌恶的习得保持完好。在实验2中，证明了拮抗剂化合物的剂量依赖性和立体选择性。这些结果与先前的研究一致，先前研究表明，基底外侧杏仁核损伤或通过其他途径（全身或脑室内）用NMDA拮抗剂治疗会在味觉增强气味条件反射中产生选择性缺陷。
