Volm M, van Kaick G, Mattern J
German Cancer Research Center, Heidelberg.
Clin Exp Metastasis. 1994 Jul;12(4):329-34. doi: 10.1007/BF01753840.
The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly higher frequency in metastases than in primary lung tumors. Gross differences were not found between primary tumors and metastatic tumors with regard to the expression of c-erbB1, c-erbB2 and c-fos. The finding of cases with a higher expression of c-jun and c-myc in lymph nodes suggests that metastatic capability may be higher in certain cell populations.
本研究的目的是确定21例原发性肺癌及其同时出现的转移淋巴结中原癌基因（c-fos、c-jun、c-erbB1、c-erbB2和c-myc）在蛋白质水平上可能存在的改变。分析表明，c-jun和c-myc蛋白在转移灶中的表达频率显著高于原发性肺肿瘤。原发性肿瘤和转移瘤在c-erbB1、c-erbB2和c-fos的表达方面未发现明显差异。淋巴结中c-jun和c-myc表达较高的病例的发现表明，某些细胞群体的转移能力可能更高。
