Volm M, Drings P, Wodrich W, van Kaick G
German Cancer Research Center, Heidelberg.
Clin Exp Metastasis. 1993 Jul;11(4):325-9. doi: 10.1007/BF00058052.
In the current study the relationship between the incidence of metastatic spread and expression (at the protein level) of various proto-oncogenes was investigated in 217 human non-small cell lung carcinomas. Tumors with an overexpression of proteins encoded by the oncogenes c-jun and c-myc showed a significantly increased formation of metastases (c-jun: P = 0.008; c-myc: P = 0.018). No significant correlations were found between the expression of the c-fos, c-erbB1, c-neu and c-ras products and metastatic spread.
在本研究中，对217例人类非小细胞肺癌患者转移扩散发生率与多种原癌基因（蛋白质水平）表达之间的关系进行了研究。癌基因c-jun和c-myc编码的蛋白质过表达的肿瘤发生转移的几率显著增加（c-jun：P = 0.008；c-myc：P = 0.018）。未发现c-fos、c-erbB1、c-neu和c-ras产物的表达与转移扩散之间存在显著相关性。
