Swenson D L, Kim K J, Six E W, Clegg S
Department of Microbiology, University of Iowa, Iowa City 52242.
Mol Gen Genet. 1994 Jul 25;244(2):216-8. doi: 10.1007/BF00283525.
The gene fimU, located on a recombinant plasmid carrying the Salmonella typhimurium type 1 fimbrial gene cluster is closely related to the Escherichia coli tRNA gene argU. The fimU gene complements an E. coli argU mutant that is a P2 lysogen, thereby allowing the phage P4 to grow in this strain but preventing the growth of phage lambda. In addition, fimU was shown to be involved in fimbrial expression since transformants of the E. coli argU mutant could produce fimbriae only in the presence of fimU but not in its absence, whereas in an E. coli argU+ strain fimbriation did not require the fimU gene.
位于携带鼠伤寒沙门氏菌1型菌毛基因簇的重组质粒上的fimU基因，与大肠杆菌的tRNA基因argU密切相关。fimU基因可互补一个作为P2溶原菌的大肠杆菌argU突变体，从而使噬菌体P4能在该菌株中生长，但阻止噬菌体λ生长。此外，fimU被证明参与菌毛表达，因为大肠杆菌argU突变体的转化子只有在存在fimU时才能产生菌毛，不存在时则不能，而在大肠杆菌argU+菌株中，菌毛形成不需要fimU基因。
