噬菌体P2-λ干扰所需的大肠杆菌基因。
An Escherichia coli gene required for bacteriophage P2-lambda interference.
作者信息
Ghisotti D, Zangrossi S, Sironi G
出版信息
J Virol. 1983 Dec;48(3):616-26. doi: 10.1128/JVI.48.3.616-626.1983.
Abstract
The gene old of bacteriophage P2 is known to (i) cause interference with phage lambda growth; (ii) kill recB- mutants of Escherichia coli after P2 infection; and (iii) determine increased sensitivity of P2 lysogenic cells to X-ray irradiation. In all of these phenomena, inhibition of protein synthesis occurs. We have isolated bacterial mutants, named pin (P2 interference), able to suppress all of the above-mentioned phenomena caused by the old+ gene product and the concurrent protein synthesis inhibition. Pin mutations are recessive, map at 12 min on the E. coli map, and identify a new gene. Satellite bacteriophage P4 does not plate on pin-3 mutant strains and causes cell lethality and protein synthesis inhibition in such mutants. P4 mutants able to grow on pin-3 strains have been isolated.
摘要
已知噬菌体P2的old基因会：（i）干扰噬菌体λ的生长；（ii）在P2感染后杀死大肠杆菌的recB -突变体；以及（iii）使P2溶原性细胞对X射线照射的敏感性增加。在所有这些现象中，都会发生蛋白质合成的抑制。我们分离出了名为pin（P2干扰）的细菌突变体，它能够抑制由old +基因产物引起的上述所有现象以及同时发生的蛋白质合成抑制。Pin突变是隐性的，位于大肠杆菌染色体图谱的12分钟处，并鉴定出一个新基因。卫星噬菌体P4不能在pin - 3突变菌株上形成噬菌斑，并在此类突变体中导致细胞致死和蛋白质合成抑制。已经分离出了能够在pin - 3菌株上生长的P4突变体。
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