普萘洛尔后对二氧化碳的呼吸反应降低：一种中枢作用。
Reduced respiratory responses to carbon dioxide after propranolol: a central action.
作者信息
Mustchin C P, Gribbin H R, Tattersfield A E, George C F
出版信息
Br Med J. 1976 Nov 20;2(6046):1229-31. doi: 10.1136/bmj.2.6046.1229.
Abstract
In a double-blind study in six subjects propranolol significantly reduced the respiratory sensitivity to carbon dioxide rebreathing. This effect seems to have been due to beta-adrenergic blockade, since it was not seen with D-propranolol. In two subjects increasing doses of propranolol caused progressive reductions in respiratory sensitivity to values below normal and similar to those of patients with ventilatory failure. These changes are probably due to a central action of propranolol.
摘要
在一项针对6名受试者的双盲研究中，普萘洛尔显著降低了对二氧化碳再呼吸的呼吸敏感性。这种效应似乎是由于β-肾上腺素能阻滞引起的，因为在D-普萘洛尔中未观察到这种效应。在两名受试者中，普萘洛尔剂量增加导致呼吸敏感性逐渐降低至低于正常水平，且与通气衰竭患者的水平相似。这些变化可能是由于普萘洛尔的中枢作用所致。
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本文引用的文献
1
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Lancet. 1964 Nov 21;2(7369):1101-2. doi: 10.1016/s0140-6736(64)92617-0.
2
Some observations on the mechanism of adrenaline hyperpnoea.关于肾上腺素性呼吸急促机制的一些观察
J Physiol. 1957 Aug 6;137(3):374-95. doi: 10.1113/jphysiol.1957.sp005820.
3
The effect of adrenaline and noradrenaline infusions on respiration in man.肾上腺素和去甲肾上腺素输注对人体呼吸的影响。
Br J Pharmacol Chemother. 1953 Mar;8(1):98-102. doi: 10.1111/j.1476-5381.1953.tb00759.x.
4
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5
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J Appl Physiol. 1967 Jul;23(1):53-70. doi: 10.1152/jappl.1967.23.1.53.
6
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7
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