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1
Reduced respiratory responses to carbon dioxide after propranolol: a central action.普萘洛尔后对二氧化碳的呼吸反应降低：一种中枢作用。
Br Med J. 1976 Nov 20;2(6046):1229-31. doi: 10.1136/bmj.2.6046.1229.
2
Is there central respiratory depression after intravenous administration of propranolol?静脉注射普萘洛尔后是否存在中枢性呼吸抑制？
Respiration. 1990;57(2):65-9. doi: 10.1159/000195822.
3
Central ventilatory depression by oral propranolol.口服普萘洛尔引起的中枢性通气抑制
Clin Pharmacol Ther. 1981 Dec;30(6):758-64. doi: 10.1038/clpt.1981.235.
4
Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.普萘洛尔和美托洛尔未能改变对二氧化碳和运动的通气反应。
Br J Clin Pharmacol. 1980 May;9(5):493-8. doi: 10.1111/j.1365-2125.1980.tb05845.x.
5
Ineffectiveness of beta-adrenergic blockers on ventilatory response to carbon dioxide.β-肾上腺素能阻滞剂对二氧化碳通气反应的无效性。
Clin Pharmacol Ther. 1982 Sep;32(3):289-94. doi: 10.1038/clpt.1982.162.
6
Propranolol and the ventilatory response to hypoxia and hypercapnia in normal man.普萘洛尔与正常人对低氧和高碳酸血症的通气反应
Clin Sci Mol Med. 1978 Nov;55(5):491-7. doi: 10.1042/cs0550491.
7
Respiratory response to carbon dioxide after propranolol in normal subjects.正常受试者服用普萘洛尔后对二氧化碳的呼吸反应。
Respiration. 1979;37(4):197-200. doi: 10.1159/000194027.
8
Ventilatory response to hypercapnia in normal subjects after propranolol, metoprolol and oxprenolol.普萘洛尔、美托洛尔和氧烯洛尔作用于正常受试者后对高碳酸血症的通气反应。
Respiration. 1980;39(3):139-43. doi: 10.1159/000194208.
9
A comparison of the effects of propranolol and practolol on forced expiratory volume and resting heart rate in normal subjects.心得安与心得宁对正常受试者用力呼气量和静息心率影响的比较。
Arch Int Pharmacodyn Ther. 1971 May;191(1):104-10.
10
Effect of beta-adrenergic blockade on respiratory and metabolic responses to exercise.β-肾上腺素能阻滞剂对运动时呼吸和代谢反应的影响。
J Appl Physiol Respir Environ Exerc Physiol. 1981 Oct;51(4):788-93. doi: 10.1152/jappl.1981.51.4.788.

引用本文的文献

1
Centrally acting drugs in chronic airways obstruction.用于慢性气道阻塞的中枢性作用药物。
Br Med J. 1980 Nov 8;281(6250):1232-3. doi: 10.1136/bmj.281.6250.1232-a.
2
Methods in the assessment of the control of breathing.呼吸控制评估方法。
Br J Clin Pharmacol. 1980 Jan;9(1):3-9. doi: 10.1111/j.1365-2125.1980.tb04789.x.
3
Effect of acute and chronic beta-blockade on carbon dioxide sensitivity in normal man.急性和慢性β受体阻滞剂对正常男性二氧化碳敏感性的影响。
Thorax. 1980 Nov;35(11):869-72. doi: 10.1136/thx.35.11.869.
4
Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.普萘洛尔和美托洛尔未能改变对二氧化碳和运动的通气反应。
Br J Clin Pharmacol. 1980 May;9(5):493-8. doi: 10.1111/j.1365-2125.1980.tb05845.x.
5
Alterations in the oxygen deficit-oxygen debt relationships with beta-adrenergic receptor blockade in man.人体中β-肾上腺素能受体阻断对氧亏-氧债关系的影响。
J Physiol. 1984 Apr;349:375-87. doi: 10.1113/jphysiol.1984.sp015161.
6
The effects of ICI 118,587 and atenolol on the responses to exercise and on breathlessness in healthy subjects.ICI 118,587和阿替洛尔对健康受试者运动反应及呼吸困难的影响。
Br J Clin Pharmacol. 1984 Jan;17(1):37-41. doi: 10.1111/j.1365-2125.1984.tb04996.x.
7
beta-Adrenoceptor blockade and ventilation in man.人体中的β-肾上腺素能受体阻断与通气
Br J Clin Pharmacol. 1980 Dec;10(6):624-5. doi: 10.1111/j.1365-2125.1980.tb00523.x.
8
The management of acute poisoning due to beta-adrenoceptor antagonists.β-肾上腺素能受体拮抗剂所致急性中毒的处理
Med Toxicol Adverse Drug Exp. 1989 Jan-Feb;4(1):32-45. doi: 10.1007/BF03259901.
9
Respiratory function in the elderly and the effects of beta blockade.
Cardiovasc Drugs Ther. 1991 Jan;4 Suppl 6:1229-32. doi: 10.1007/BF00114225.
10
The influence of anticoagulants and extracellular divalent cations on blood platelet behaviour [proceedings].抗凝剂和细胞外二价阳离子对血小板行为的影响[会议论文集]
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本文引用的文献

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EFFECT OF A BETA-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS.β-肾上腺素能阻滞剂普萘洛尔对哮喘患者的影响。
Lancet. 1964 Nov 21;2(7369):1101-2. doi: 10.1016/s0140-6736(64)92617-0.
2
Some observations on the mechanism of adrenaline hyperpnoea.关于肾上腺素性呼吸急促机制的一些观察
J Physiol. 1957 Aug 6;137(3):374-95. doi: 10.1113/jphysiol.1957.sp005820.
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The effect of adrenaline and noradrenaline infusions on respiration in man.肾上腺素和去甲肾上腺素输注对人体呼吸的影响。
Br J Pharmacol Chemother. 1953 Mar;8(1):98-102. doi: 10.1111/j.1476-5381.1953.tb00759.x.
4
A clinical method for assessing the ventilatory response to carbon dioxide.一种评估对二氧化碳通气反应的临床方法。
Australas Ann Med. 1967 Feb;16(1):20-32. doi: 10.1111/imj.1967.16.1.20.
5
Blood-brain tissue Pco2 relationships and ventilation during rebreathing.重复呼吸期间血脑屏障组织二氧化碳分压关系及通气情况
J Appl Physiol. 1967 Jul;23(1):53-70. doi: 10.1152/jappl.1967.23.1.53.
6
Effect of propranolol on ventilatory function.普萘洛尔对通气功能的影响。
Am J Cardiol. 1966 Sep;18(3):473-5. doi: 10.1016/0002-9149(66)90072-5.
7
Effects of beta-adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects.β-肾上腺素能受体阻滞剂对正常人和哮喘患者气道传导率及肺容积的影响。
Br Med J. 1969 Jul 19;3(5663):143-5. doi: 10.1136/bmj.3.5663.143.
8
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
9
Chemoreflex ventilatory response to CO 2 in man at low and high altitudes.低海拔和高海拔地区人体对二氧化碳的化学反射性通气反应。
Respir Physiol. 1972 Apr;14(3):296-306. doi: 10.1016/0034-5687(72)90036-9.
10
The effect of propranolol on airway resistance.普萘洛尔对气道阻力的影响。
Br J Anaesth. 1967 Dec;39(12):919-26. doi: 10.1093/bja/39.12.919.

普萘洛尔后对二氧化碳的呼吸反应降低：一种中枢作用。

Reduced respiratory responses to carbon dioxide after propranolol: a central action.

作者信息

Mustchin C P, Gribbin H R, Tattersfield A E, George C F

出版信息

Br Med J. 1976 Nov 20;2(6046):1229-31. doi: 10.1136/bmj.2.6046.1229.

DOI:10.1136/bmj.2.6046.1229
PMID:791448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1689763/
Abstract

In a double-blind study in six subjects propranolol significantly reduced the respiratory sensitivity to carbon dioxide rebreathing. This effect seems to have been due to beta-adrenergic blockade, since it was not seen with D-propranolol. In two subjects increasing doses of propranolol caused progressive reductions in respiratory sensitivity to values below normal and similar to those of patients with ventilatory failure. These changes are probably due to a central action of propranolol.

摘要

在一项针对6名受试者的双盲研究中，普萘洛尔显著降低了对二氧化碳再呼吸的呼吸敏感性。这种效应似乎是由于β-肾上腺素能阻滞引起的，因为在D-普萘洛尔中未观察到这种效应。在两名受试者中，普萘洛尔剂量增加导致呼吸敏感性逐渐降低至低于正常水平，且与通气衰竭患者的水平相似。这些变化可能是由于普萘洛尔的中枢作用所致。