来自人类染色体带13q12的酵母人工染色体的特征分析，该染色体包含FLT1和FLT3受体型酪氨酸激酶基因。
Characterization of a yeast artificial chromosome from human chromosome band 13q12 containing the FLT1 and FLT3 receptor-type tyrosine kinase genes.
作者信息
Imbert A, Rosnet O, Marchetto S, Ollendorff V, Birnbaum D, Pébusque M J
机构信息
Laboratoire d'Oncologie Moléculaire, U.119 INSERM, Marseille, France.
出版信息
Cytogenet Cell Genet. 1994;67(3):175-7. doi: 10.1159/000133817.
A yeast artificial chromosome containing the two receptor-type tyrosine kinase genes FLT1 and FLT3 was isolated, analyzed, and compared to a genomic map in order to establish their organization and linkage. FLT1 and FLT3 are physically linked in a head-to-tail configuration and separated by about 150 kb. The region contains three CpG islands. Two of them are likely to correspond to FLT1 and FLT3, whereas the third one is suggestive of another putative, unidentified RTK gene.
分离出一个包含两个受体型酪氨酸激酶基因FLT1和FLT3的酵母人工染色体，进行分析并与基因组图谱比较，以确定它们的结构和连锁关系。FLT1和FLT3在物理上以头对尾的形式相连，间隔约150 kb。该区域包含三个CpG岛。其中两个可能分别对应FLT1和FLT3，而第三个提示存在另一个假定的、未鉴定的RTK基因。
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