Carow C E, Kim E, Hawkins A L, Webb H D, Griffin C A, Jabs E W, Civin C I, Small D
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cytogenet Cell Genet. 1995;70(3-4):255-7. doi: 10.1159/000134046.
We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12-->q13.
我们先前已报道了干细胞酪氨酸激酶-1（STK-1，基因符号FLT3）的克隆，它是小鼠Flk2/Flt3基因的人类同源物（Small等人，1994年）。这种生长因子受体在CD34+人类骨髓（干细胞/祖细胞）中表达。我们通过对人-啮齿动物体细胞杂交板进行PCR筛选，以及将STK-1基因组探针与正常人淋巴细胞的有丝分裂染色体进行荧光原位分子杂交（FISH），对STK-1基因进行了定位。两项分析结果均显示，STK-1（FLT3）基因定位于染色体13q12→q13。
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