格陵兰的DNA多态性。使用VNTR探针MS1、MS31、MS43a和YNH24对格陵兰人群样本中的等位基因和图谱频率进行研究。

DNA polymorphism in Greenland. Allele and profile frequencies in a Greenland population sample using the VNTR probes MS1, MS31, MS43a and YNH24.

作者信息

Eriksen B, Svensmark O

机构信息

Institute of Forensic Genetics, University of Copenhagen, Denmark.

出版信息

Int J Legal Med. 1994;106(5):254-7. doi: 10.1007/BF01225415.

DOI:10.1007/BF01225415

PMID:7915134

Abstract

Allele frequencies obtained by RFLP (Restriction Fragment Length Polymorphism) analysis using the VNTR (Variable Number Tandem Repeats) single locus probes MS1, MS31, MS43a and YNH24 on HinfI-restricted DNA in a Greenland Eskimo (155 individuals) and a Danish Caucasian (616 individuals) population sample are reported. For MS1 the frequency distributions were almost identical whereas minor but significant differences were seen for the other 3 probes. The distribution of the frequencies of 139 Greenland complete DNA profiles was estimated using the Greenland and the Danish database. The average profile frequencies obtained with the Greenland database were approximately 10 times higher than the estimates obtained with the Danish database.

摘要

报告了在格陵兰爱斯基摩人（155人）和丹麦高加索人（616人）的人群样本中，使用VNTR（可变数目串联重复序列）单基因座探针MS1、MS31、MS43a和YNH24，对经HinfI限制的DNA进行RFLP（限制性片段长度多态性）分析所获得的等位基因频率。对于MS1，频率分布几乎相同，而对于其他3种探针则观察到微小但显著的差异。利用格陵兰和丹麦数据库估计了139个格陵兰完整DNA图谱的频率分布。使用格陵兰数据库获得的平均图谱频率比使用丹麦数据库获得的估计值高约10倍。