French K A, Kristan W B
Department of Biology, University of California, San Diego, La Jolla 92093-0357.
J Neurobiol. 1994 Jun;25(6):640-51. doi: 10.1002/neu.480250606.
Mitotic lineage has been found to determine the cellular identity of leech neurons (reviewed in Stent et al., 1992), Int. Rev. Neurobiol. 33:109-133. However, the details of the adult phenotype of many neurons in the central nervous system of the leech have been shown to be shaped by interactions either with other neurons or with non-neuronal tissues in the environment. Four effects of cell-cell interactions will be considered in this article: stimulation of mitosis that generates new neurons, modulation of cell death or axonal retraction, modification of neurotransmitter metabolism, and modification of other physiological properties. In all cases, the interactions that modify development are thought to occur at a location distant from the soma, requiring that signals be transmitted a significant distance from the site of interaction to the metabolic machinery in the soma.
有丝分裂谱系已被发现可决定水蛭神经元的细胞特性（见Stent等人，1992年综述，《国际神经生物学评论》33:109 - 133）。然而，水蛭中枢神经系统中许多神经元的成年表型细节已表明是由与其他神经元或环境中非神经元组织的相互作用所塑造的。本文将考虑细胞间相互作用的四种效应：刺激产生新神经元的有丝分裂、调节细胞死亡或轴突回缩、改变神经递质代谢以及改变其他生理特性。在所有情况下，被认为改变发育的相互作用发生在远离胞体的位置，这就要求信号从相互作用位点远距离传输到胞体中的代谢机制。
