[胰岛素和肾上腺素对大鼠器官中谷胱甘肽代谢酶活性及谷胱甘肽浓度的影响]
[Effect of insulin and adrenaline on the activity of enzymes of glutathione metabolism and glutathione concentration in rat organs].
作者信息
Kolesnichenko L S, Kulinskiĭ V I, Ias'ko M V, Pensionerova G A, Grudinina Iu V
出版信息
Probl Endokrinol (Mosk). 1994 May-Jun;40(3):42-4.
Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia.
肾上腺素可激活心脏、肝脏和肾脏中的谷胱甘肽过氧化物酶以及心脏和肝脏中的谷胱甘肽转移酶，抑制肾脏中的γ-谷氨酰转移酶，对谷胱甘肽还原酶无影响；未检测到大脑有变化。胰岛素也不影响谷胱甘肽还原酶，在心脏、肝脏和骨髓中也未引起任何变化，但在许多情况下，它会改变（通常是降低）多种谷胱甘肽代谢酶的活性，并在注射后1小时和24小时降低大脑、肾脏和脾脏中的谷胱甘肽浓度。检测到的变化不符合普遍认可的胰岛素敏感性器官分类，也与低血糖无关。
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