Boĭtsova L V
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
Ukr Biokhim Zh (1978). 1998 Jan-Feb;70(1):113-7.
Dynamics of changes of the reduced glutathione contents, activity of glutathione transferase, glutathione reductase and gamma-glutamyl transpeptidase in rat organs at a single injection of embiquine in a dose of 1/2 LD50 has been studied. It was shown that injection of the alkylating antitumor preparation lead to the decrease of the reduced glutathione contents in the early period of intoxication together with compensatory increase of tripeptide concentrations 3 hours later in the liver tissue and 24 hours later in the kidney tissue. Embiquine caused the steady increase of the glutathione transferase activity in all the organs studied. Significant increase of liver, kidney and spleen gamma-glutamyl transpeptidase by the end of the investigation period was noted at the injection of the alkylating agent.
研究了以1/2 LD50剂量单次注射恩比喹后大鼠器官中还原型谷胱甘肽含量、谷胱甘肽转移酶、谷胱甘肽还原酶和γ-谷氨酰转肽酶活性的变化动态。结果表明，注射烷基化抗肿瘤制剂导致中毒早期还原型谷胱甘肽含量降低，3小时后肝组织和24小时后肾组织中三肽浓度代偿性增加。恩比喹使所有研究器官中的谷胱甘肽转移酶活性持续增加。在注射烷基化剂后，在研究期末发现肝脏、肾脏和脾脏的γ-谷氨酰转肽酶显著增加。
