Ciuffetti G, Paltriccia R, Lombardini R, Lupattelli G, Pasqualini L, Mannarino E
Department of Internal Medicine, University of Perugia, Italy.
Int Angiol. 1994 Mar;13(1):33-9.
The effects of three months therapy with Pentoxifylline (800 mg three times daily) and physical training were compared in two age- and sex-matched groups of Stage II PAOD patients. Before therapy and after 12 and 13 weeks each patient underwent a standard treadmill test. The maximum walking time, TcPO2 half recovery time to basal values after the induced ischaemia, granulocyte production of free radicals (by the superoxide dismutase-inhibitable reduction of ferricytochrome) and surface expression of the CD11/CD18 complex of adhesion molecules (by using specific monoclonal antibodies) were determined. Pentoxifylline inhibited free radical production and reduced the percentage of granulocytes expressing adhesion receptors while exercise had no significant effect on these parameters. These changes, which reflect improved microcirculatory functioning, were associated with a greater walking capacity and shorter half recovery time (+14% vs exercise group, p < 0.01; -39% vs exercise group, p < 0.01 respectively).
在两组年龄和性别匹配的II期外周动脉闭塞性疾病（PAOD）患者中，比较了己酮可可碱（每日三次，每次800毫克）三个月治疗和体育锻炼的效果。在治疗前以及治疗12周和13周后，每位患者都接受了标准的跑步机测试。测定了最大行走时间、诱导缺血后TcPO2恢复至基础值的一半时间、粒细胞产生自由基的情况（通过超氧化物歧化酶抑制的铁细胞色素还原法）以及粘附分子CD11/CD18复合物的表面表达情况（使用特异性单克隆抗体）。己酮可可碱抑制自由基产生并降低表达粘附受体的粒细胞百分比，而运动对这些参数没有显著影响。这些反映微循环功能改善的变化与更大的行走能力和更短的恢复一半时间相关（分别比运动组增加14%，p < 0.01；比运动组减少39%，p < 0.01）。
