感染性休克患者混合静脉血氧饱和度与肝静脉血氧饱和度之间的关系。

The relationship between mixed venous and hepatic venous O2 saturation in patients with septic shock.

作者信息

Meier-Hellmann A, Hannemann L, Specht M, Schaffartzik W, Spies C, Reinhart K

机构信息

Department of Anesthesiology and Surgical Intensive Care Medicine, Steglitz Medical Center, Free University of Berlin, Germany.

出版信息

Adv Exp Med Biol. 1994;345:701-7. doi: 10.1007/978-1-4615-2468-7_92.

DOI:10.1007/978-1-4615-2468-7_92

PMID:7915869

Abstract

It was the purpose of this study to measure the relationship between hepatic venous O2 saturation (ShvO2) and mixed venous O2 saturation (SvO2) in septic patients (n = 21) following treatment with various catecholamines (epinephrine, norepinephrine, dopamine, dopexamine). At baseline mean SvO2 was 74 +/- 5% while mean ShvO2 was 59 +/- 12%. Alpha-mimetic substances such as epinephrine and norepinephrine reduced ShvO2 and increased the difference between SvO2 and ShvO2.Beta2-mimetic and dopaminergic substances (dopexamine, dopamine) did not change the difference between SvO2 and ShvO2. These results show that SvO2 does not necessarily reflect all changes of ShvO2. Monitoring ShvO2 may be helpful in managing septic shock by adding information on adequacy of O2 supply/consumption ratio in the crucial splanchnic region.

摘要

本研究旨在测量21例脓毒症患者在接受各种儿茶酚胺（肾上腺素、去甲肾上腺素、多巴胺、多培沙明）治疗后肝静脉血氧饱和度（ShvO2）与混合静脉血氧饱和度（SvO2）之间的关系。基线时，平均SvO2为74±5%，而平均ShvO2为59±12%。肾上腺素和去甲肾上腺素等α-拟交感物质降低了ShvO2，并增加了SvO2与ShvO2之间的差值。β2-拟交感和多巴胺能物质（多培沙明、多巴胺）未改变SvO2与ShvO2之间的差值。这些结果表明，SvO2不一定反映ShvO2的所有变化。监测ShvO2可能有助于通过补充关键内脏区域氧供/氧耗比充足性的信息来管理脓毒症休克。