人类白细胞抗原I类分子在人类免疫缺陷病毒感染CD4阳性细胞中的作用。
Involvement of human leukocyte antigen class I molecules in human immunodeficiency virus infection of CD4-positive cells.
作者信息
Benkirane M, Blanc-Zouaoui D, Hirn M, Devaux C
机构信息
Centre de Tri des Molécules anti-HIV, Institut National de la Santé et de la Recherche Médicale U249, Montpellier, France.
出版信息
J Virol. 1994 Oct;68(10):6332-9. doi: 10.1128/JVI.68.10.6332-6339.1994.
Abstract
We have studied the putative roles of human immunodeficiency virus (HIV)-associated and cell surface-expressed major histocompatibility complex class I (MHC-I) molecules in the course of the HIV life cycle by the combined use of MHC-I molecule-positive and MHC-I molecule-negative virus particles and MHC-I molecule-positive and MHC-I molecule-negative CD4+ human cells. We found (i) that several anti-MHC-I monoclonal antibodies neutralize cell infection by direct interaction with HIV-associated MHC-I antigens, (ii) that these HIV-associated MHC-I antigens are however dispensable for cell infection, and (iii) that the cell surface-expressed MHC-I molecules are unnecessary for productive infection of CD4+ human cells. These results clarify further the functions of MHC-I molecules during the HIV life cycle.
摘要
我们通过联合使用MHC-I分子阳性和MHC-I分子阴性病毒颗粒以及MHC-I分子阳性和MHC-I分子阴性CD4⁺人类细胞，研究了人类免疫缺陷病毒（HIV）相关的以及细胞表面表达的主要组织相容性复合体I类（MHC-I）分子在HIV生命周期中的假定作用。我们发现：（i）几种抗MHC-I单克隆抗体通过与HIV相关的MHC-I抗原直接相互作用来中和细胞感染；（ii）然而，这些HIV相关的MHC-I抗原对于细胞感染是可有可无的；（iii）细胞表面表达的MHC-I分子对于CD4⁺人类细胞的有效感染是不必要的。这些结果进一步阐明了MHC-I分子在HIV生命周期中的功能。
相似文献
1
Involvement of human leukocyte antigen class I molecules in human immunodeficiency virus infection of CD4-positive cells.人类白细胞抗原I类分子在人类免疫缺陷病毒感染CD4阳性细胞中的作用。
J Virol. 1994 Oct;68(10):6332-9. doi: 10.1128/JVI.68.10.6332-6339.1994.
2
Role of class I major histocompatibility complex-restricted and -unrestricted suppression of human immunodeficiency virus type 1 replication by CD8+ T lymphocytes.I类主要组织相容性复合体限制和非限制的CD8 + T淋巴细胞对1型人类免疫缺陷病毒复制的抑制作用
J Gen Virol. 1999 Jan;80 ( Pt 1):209-216. doi: 10.1099/0022-1317-80-1-209.
3
4
Downregulation of major histocompatibility class I on human dendritic cells by HIV Nef impairs antigen presentation to HIV-specific CD8+ T lymphocytes.HIV Nef蛋白使人类树突状细胞上的主要组织相容性复合体I类分子下调，从而削弱了向HIV特异性CD8 + T淋巴细胞的抗原呈递。
AIDS Res Hum Retroviruses. 2001 Sep 20;17(14):1365-70. doi: 10.1089/08892220152596623.
5
Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.HIV-1的Nef蛋白对原代静息CD4+ T淋巴细胞中特定表面受体的调节及激活致敏作用。
J Leukoc Biol. 2006 Mar;79(3):616-27. doi: 10.1189/jlb.0805461. Epub 2005 Dec 19.
6
Enhanced HIV infectivity and changes in GP120 conformation associated with viral incorporation of human leucocyte antigen class I molecules.与人类白细胞抗原I类分子的病毒掺入相关的HIV感染性增强及GP120构象变化。
AIDS. 1999 Oct 22;13(15):2033-42. doi: 10.1097/00002030-199910220-00005.
7
Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection.HIV-1感染后CD4+ T细胞系CEM-E5中MHC-I的下调。
J Immunol. 1989 Nov 1;143(9):2858-66.
8
Inhibition of human immunodeficiency virus type 1 production in infected peripheral blood mononuclear cells by human leukocyte antigen class I-specific antibodies: evidence for a novel antiviral mechanism.人类白细胞抗原I类特异性抗体对感染的外周血单个核细胞中1型人类免疫缺陷病毒产生的抑制作用：一种新型抗病毒机制的证据。
J Virol. 1996 Aug;70(8):5213-20. doi: 10.1128/JVI.70.8.5213-5220.1996.
9
In vitro infection of natural killer cells with different human immunodeficiency virus type 1 isolates.用不同的1型人类免疫缺陷病毒分离株对自然杀伤细胞进行体外感染。
J Virol. 1991 Apr;65(4):1812-22. doi: 10.1128/JVI.65.4.1812-1822.1991.
10
Major histocompatibility complex class I-restricted alloreactive CD4+ T cells.主要组织相容性复合体I类限制性同种异体反应性CD4+ T细胞
Immunology. 2004 May;112(1):54-63. doi: 10.1111/j.1365-2567.2004.01857.x.
引用本文的文献
1
Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo.在实验室及临床1型人类免疫缺陷病毒毒株中存在的宿主细胞间黏附分子-1（ICAM-1），会增加人类淋巴组织中病毒的感染性及CD4(+) T细胞的耗竭，而淋巴组织是该病毒在体内主要的复制场所。
J Virol. 2002 Feb;76(3):1004-14. doi: 10.1128/jvi.76.3.1004-1014.2002.
2
Level of ICAM-1 surface expression on virus producer cells influences both the amount of virion-bound host ICAM-1 and human immunodeficiency virus type 1 infectivity.病毒产生细胞上细胞间黏附分子-1（ICAM-1）的表面表达水平既影响病毒体结合的宿主ICAM-1的量，也影响1型人类免疫缺陷病毒的感染性。
J Virol. 1998 Nov;72(11):9329-36. doi: 10.1128/JVI.72.11.9329-9336.1998.
3
T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1.表达活化淋巴细胞功能相关抗原-1的T细胞更容易被携带宿主编码细胞间黏附分子-1的1型人类免疫缺陷病毒颗粒感染。
J Virol. 1998 Mar;72(3):2105-12. doi: 10.1128/JVI.72.3.2105-2112.1998.
4
Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity.整合到1型人类免疫缺陷病毒上的宿主来源的细胞间黏附分子-1糖蛋白具有生物活性，并增强病毒感染性。
J Virol. 1997 May;71(5):3588-96. doi: 10.1128/JVI.71.5.3588-3596.1997.
5
Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway.1型人类免疫缺陷病毒与CD4的结合会诱导Lck和Raf-1的结合，并通过一条不依赖Ras的途径激活Raf-1。
Mol Cell Biol. 1996 Nov;16(11):6532-41. doi: 10.1128/MCB.16.11.6532.
6
Inhibition of human immunodeficiency virus type 1 production in infected peripheral blood mononuclear cells by human leukocyte antigen class I-specific antibodies: evidence for a novel antiviral mechanism.人类白细胞抗原I类特异性抗体对感染的外周血单个核细胞中1型人类免疫缺陷病毒产生的抑制作用：一种新型抗病毒机制的证据。
J Virol. 1996 Aug;70(8):5213-20. doi: 10.1128/JVI.70.8.5213-5220.1996.
7
The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells.CD4的胞质结构域在HIV感染T细胞的早期阶段起着关键作用。
EMBO J. 1994 Dec 1;13(23):5559-69. doi: 10.1002/j.1460-2075.1994.tb06893.x.
8
Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1.病毒体相关糖基磷脂酰肌醇连接蛋白CD55和CD59在HIV-1细胞系衍生株和原代分离株补体抗性中的作用
J Exp Med. 1995 Aug 1;182(2):501-9. doi: 10.1084/jem.182.2.501.
9
The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4.CD4的胞质尾部是通过与CD4第1结构域中免疫球蛋白CDR3样区域结合的抗体抑制1型人类免疫缺陷病毒复制所必需的。
J Virol. 1995 Nov;69(11):6904-10. doi: 10.1128/JVI.69.11.6904-6910.1995.
本文引用的文献
1
Protection of monkeys by a split vaccine against SIVmac depends upon biological properties of the challenge virus.一种针对猴免疫缺陷病毒（SIVmac）的裂解疫苗对猴子的保护作用取决于攻击病毒的生物学特性。
AIDS. 1993 Jun;7(6):787-95. doi: 10.1097/00002030-199306000-00005.
2
Human immunodeficiency virus type 1 gp120 C5 region mimics the HLA class I alpha 1 peptide-binding domain.1型人类免疫缺陷病毒糖蛋白120 C5区模拟HLA I类α1肽结合结构域。
Eur J Immunol. 1993 Aug;23(8):2016-21. doi: 10.1002/eji.1830230844.
3
Anti-cellular antibodies in sera from vaccinated macaques can induce complement-mediated virolysis of human immunodeficiency virus and simian immunodeficiency virus.接种疫苗的猕猴血清中的抗细胞抗体可诱导补体介导的人免疫缺陷病毒和猴免疫缺陷病毒的病毒溶解。
Virology. 1993 Aug;195(2):475-80. doi: 10.1006/viro.1993.1398.
4
Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV.宿主细胞表面黏附受体及其他膜蛋白与HIV和SIV的关联。
AIDS Res Hum Retroviruses. 1993 Nov;9(11):1157-65. doi: 10.1089/aid.1993.9.1157.
5
Host cell membrane proteins on human immunodeficiency virus type 1 after in vitro infection of H9 cells and blood mononuclear cells. An immuno-electron microscopic study.人免疫缺陷病毒1型体外感染H9细胞和血液单核细胞后宿主细胞膜蛋白。免疫电镜研究。
J Gen Virol. 1993 Jan;74 ( Pt 1):129-35. doi: 10.1099/0022-1317-74-1-129.
6
Ig CDR3-like region of the CD4 molecule is involved in HIV-induced syncytia formation but not in viral entry.CD4分子的免疫球蛋白互补决定区3样区域参与HIV诱导的合胞体形成，但不参与病毒进入。
J Immunol. 1993 Jan 1;150(1):290-301.
7
An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells.一种与CD4分子的免疫球蛋白CDR3样区域结合的抗体可抑制HIV感染的T细胞中的前病毒转录。
EMBO J. 1993 Dec 15;12(13):4909-21. doi: 10.1002/j.1460-2075.1993.tb06185.x.
8
Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.淋巴结病相关病毒（LAV）对辅助诱导性T淋巴细胞的选择性嗜性。
Science. 1984 Jul 6;225(4657):59-63. doi: 10.1126/science.6328660.
9
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.从艾滋病患者和有患艾滋病风险的人群中频繁检测和分离出细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):500-3. doi: 10.1126/science.6200936.
10
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征（艾滋病）风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.
Zotero 插件