Suzui H, Takahashi J A, Fukumoto M, Hashimoto N, Itoh N, Hatanaka M, Kikuchi H
Department of Neurosurgery, Faculty of Medicine, Kyoto University, Japan.
Neurosci Lett. 1994 Apr 25;171(1-2):192-6. doi: 10.1016/0304-3940(94)90637-8.
Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (X2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.
在垂体腺瘤中进行了碱性成纤维细胞生长因子（bFGF）及其一种受体（FGFR-I）的免疫组织化学和逆转录聚合酶链反应（RT-PCR）检测。60%的垂体腺瘤对bFGF呈强或中度免疫反应性。肿瘤组织中FGFR-I的免疫反应性与bFGF的免疫反应性呈正相关（X2 = 6.176，P = 0.0456）。碱性FGF阳性细胞由垂体腺瘤细胞以及滤泡星状细胞组成，且它们的分布是异质性的。bFGF和FGFR-I的表达与垂体腺瘤的细胞增殖或所产生的激素无关，这表明bFGF在垂体腺瘤进展之外发挥着某种作用。
