• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The structural and functional organization of intramolecular chaperones: the N-terminal propeptides which mediate protein folding.

作者信息

Shinde U, Inouye M

机构信息

Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.

出版信息

J Biochem. 1994 Apr;115(4):629-36. doi: 10.1093/oxfordjournals.jbchem.a124386.

DOI:10.1093/oxfordjournals.jbchem.a124386
PMID:7916340
Abstract

A large number of prokaryotic as well as eukaryotic proteins are produced with amino terminal propeptides. These amino-terminal extensions are essential for mediating proper folding of their corresponding proteins and are also termed as intramolecular chaperones. Though these propeptides are highly specific and unique in their function, several common features have been identified and indicate that the overall mechanism by which they function may be very similar.

摘要

相似文献

1
The structural and functional organization of intramolecular chaperones: the N-terminal propeptides which mediate protein folding.
J Biochem. 1994 Apr;115(4):629-36. doi: 10.1093/oxfordjournals.jbchem.a124386.
2
Intramolecular chaperones and protein folding.分子内伴侣与蛋白质折叠
Trends Biochem Sci. 1993 Nov;18(11):442-6. doi: 10.1016/0968-0004(93)90146-e.
3
Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability.在真核细胞周期调控、去帽和RNA稳定性中具有预测作用的蛋白质中的新型保守结构域。
BMC Genomics. 2004 Jul 16;5(1):45. doi: 10.1186/1471-2164-5-45.
4
Intramolecular chaperones: polypeptide extensions that modulate protein folding.分子内伴侣：调节蛋白质折叠的多肽延伸段。
Semin Cell Dev Biol. 2000 Feb;11(1):35-44. doi: 10.1006/scdb.1999.0349.
5
Folding pathway mediated by an intramolecular chaperone. A functional peptide chaperone designed using sequence databases.由分子内伴侣介导的折叠途径。利用序列数据库设计的功能性肽伴侣。
J Biol Chem. 2003 Apr 25;278(17):15246-51. doi: 10.1074/jbc.M212003200. Epub 2003 Feb 11.
6
Six new candidate members of the alpha/beta twisted open-sheet family detected by sequence similarity to flavodoxin.通过与黄素氧还蛋白的序列相似性检测到的α/β扭曲开放片层家族的六个新候选成员。
Protein Sci. 1994 Dec;3(12):2185-93. doi: 10.1002/pro.5560031204.
7
Circular permutations of protein sequence: not so rare?蛋白质序列的环形排列：并非那么罕见？
Trends Biochem Sci. 1995 Sep;20(9):349-50. doi: 10.1016/s0968-0004(00)89073-8.
8
Structural and functional homology between periplasmic bacterial molecular chaperones and small heat shock proteins.
FEMS Immunol Med Microbiol. 1995 Jul;11(4):265-72. doi: 10.1111/j.1574-695X.1995.tb00155.x.
9
Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease.序列比对和同源穿线法揭示了与乳糖通透酶相似的原核生物和真核生物蛋白质。
J Mol Biol. 2006 May 12;358(4):1060-70. doi: 10.1016/j.jmb.2006.02.049. Epub 2006 Mar 9.
10
Mycobacterial chaperonins: the tail wags the dog.分枝杆菌分子伴侣：尾摇狗。
FEMS Microbiol Lett. 2014 Jan;350(1):20-4. doi: 10.1111/1574-6968.12276. Epub 2013 Oct 7.

引用本文的文献

1
A novel subtilase inhibitor in plants shows structural and functional similarities to protease propeptides.植物中一种新型枯草杆菌蛋白酶抑制剂与蛋白酶原肽在结构和功能上具有相似性。
J Biol Chem. 2017 Apr 14;292(15):6389-6401. doi: 10.1074/jbc.M117.775445. Epub 2017 Feb 21.
2
Functional Characterization of Propeptides in Plant Subtilases as Intramolecular Chaperones and Inhibitors of the Mature Protease.植物枯草杆菌蛋白酶中前肽作为分子内伴侣和成熟蛋白酶抑制剂的功能表征
J Biol Chem. 2016 Sep 9;291(37):19449-61. doi: 10.1074/jbc.M116.744151. Epub 2016 Jul 22.
3
Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin.
来自细菌枯草杆菌蛋白酶对弗林蛋白酶分子内伴侣介导激活机制的见解。
Methods Mol Biol. 2011;768:59-106. doi: 10.1007/978-1-61779-204-5_4.
4
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.同义突变和核糖体停滞可导致折叠途径改变和不同的最低能量状态。
J Mol Biol. 2008 Nov 7;383(2):281-91. doi: 10.1016/j.jmb.2008.08.012. Epub 2008 Aug 12.
5
Identification of furin pro-region determinants involved in folding and activation.鉴定参与折叠和激活的弗林蛋白酶前体区域决定因素。
Biochem J. 2004 May 1;379(Pt 3):757-63. doi: 10.1042/BJ20031902.
6
Alpha-crystallin binds to the aggregation-prone molten-globule state of alkaline protease: implications for preventing irreversible thermal denaturation.α-晶状体蛋白与碱性蛋白酶易于聚集的熔融球状状态结合：对防止不可逆热变性的意义。
Protein Sci. 2002 Jul;11(7):1720-8. doi: 10.1110/ps.0201802.
7
Partial characterization of an enzyme fraction with protease activity which converts the spore peptidoglycan hydrolase (SleC) precursor to an active enzyme during germination of Clostridium perfringens S40 spores and analysis of a gene cluster involved in the activity.产气荚膜梭菌S40孢子萌发过程中一种具有蛋白酶活性的酶组分的部分特性，该酶组分可将孢子肽聚糖水解酶（SleC）前体转化为活性酶，并对参与该活性的基因簇进行分析。
J Bacteriol. 2001 Jun;183(12):3742-51. doi: 10.1128/JB.183.12.3742-3751.2001.
8
Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2.前激素原PC2和前激素原PC3自身催化裂解的差异可归因于前肽内的序列以及前激素原PC2的天冬氨酸310。
Biochem J. 1998 Sep 15;334 ( Pt 3)(Pt 3):531-7. doi: 10.1042/bj3340531.
9
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.哺乳动物20S蛋白酶体生物合成的分析：β亚基的成熟是一个涉及自催化的有序两步机制。
EMBO J. 1996 Dec 16;15(24):6887-98.
10
Characterization of the regulatory region of a cell interaction-dependent gene in Myxococcus xanthus.黄色粘球菌中细胞相互作用依赖性基因调控区的表征
J Bacteriol. 1996 May;178(9):2539-50. doi: 10.1128/jb.178.9.2539-2550.1996.