Ebens A J, Garren H, Cheyette B N, Zipursky S L
Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, School of Medicine, Los Angeles 90024-1737.
Cell. 1993 Jul 16;74(1):15-27. doi: 10.1016/0092-8674(93)90291-w.
The Drosophila anachronism (ana) locus controls the proliferation of neuroblasts, neuronal stem cells that give rise to the central nervous system. In ana mutants, quiescent postembryonic central brain and optic lobe neuroblasts enter S phase precociously. ana encodes a novel secreted protein of 474 amino acids that is expressed not in the affected neuroblasts, but rather in a subclass of neighboring glial cells. These studies argue for an important role for glia in negatively regulating proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.
果蝇返祖现象（ana）基因座控制神经母细胞（即产生中枢神经系统的神经元干细胞）的增殖。在ana突变体中，静止的胚胎后中枢脑和视叶神经母细胞会过早进入S期。ana编码一种由474个氨基酸组成的新型分泌蛋白，该蛋白并非在受影响的神经母细胞中表达，而是在邻近神经胶质细胞的一个亚类中表达。这些研究表明，神经胶质细胞在负向调节神经元前体细胞的增殖中发挥重要作用，从而控制胚胎后神经发生的时间。
