Echelard Y, Epstein D J, St-Jacques B, Shen L, Mohler J, McMahon J A, McMahon A P
Harvard University, Department of Biochemistry, Molecular Biology, and Cellular and Developmental Biology, Cambridge, Massachusetts 02138.
Cell. 1993 Dec 31;75(7):1417-30. doi: 10.1016/0092-8674(93)90627-3.
We have identified three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh). Like hh, they encode putative secreted proteins and are thus implicated in cell-cell interactions. One of these, Sonic hh (Shh), is expressed in the notochord, the floor plate, and the zone of polarizing activity, signaling centers that are thought to mediate central nervous system (CNS) and limb polarity. Ectopic expression of Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results suggest that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
我们已经鉴定出与果蝇体节极性基因刺猬基因（hh）相关的一个小鼠基因家族的三个成员。与hh一样，它们编码假定的分泌蛋白，因此与细胞间相互作用有关。其中之一，即音猬因子（Shh），在脊索、底板以及极化活性区表达，这些信号中心被认为介导中枢神经系统（CNS）和肢体的极性。Shh在小鼠中枢神经系统中的异位表达导致底板表达基因的激活。这些结果表明，Shh可能在形成腹侧中枢神经系统模式的正常诱导相互作用中发挥作用。
