Krauss S, Concordet J P, Ingham P W
Molecular Embryology Laboratory, Imperial Cancer Research Fund, Oxford, England.
Cell. 1993 Dec 31;75(7):1431-44. doi: 10.1016/0092-8674(93)90628-4.
The segment polarity gene hedgehog (hh) encodes a novel signaling protein that mediates local cell-cell interactions in the developing Drosophila embryo. Here we describe the existence of an hh-related gene family in the zebrafish, Brachydanio rerio. One of these genes, sonic hedgehog (shh), is expressed in the notochord, floor plate, and posterior fin mesoderm, tissues associated with polarizing activities in various vertebrate embryos. The pattern of shh expression in zebra-fish mutants affecting axial structures, together with the consequences of its ectopic expression in normal embryos, is consistent with a role for shh in floor plate induction. By expressing shh in transgenic Drosophila embryos, we also demonstrate a strong functional conservation between the fish and fly hh genes.
节段极性基因刺猬（hh）编码一种新型信号蛋白，该蛋白介导果蝇胚胎发育过程中的局部细胞间相互作用。在此，我们描述了斑马鱼（Brachydanio rerio）中存在一个与hh相关的基因家族。其中一个基因，即音猬因子（shh），在脊索、底板和尾鳍中胚层中表达，这些组织与各种脊椎动物胚胎中的极化活动相关。shh在影响轴向结构的斑马鱼突变体中的表达模式，以及其在正常胚胎中异位表达的结果，与shh在底板诱导中的作用一致。通过在转基因果蝇胚胎中表达shh，我们还证明了鱼类和果蝇hh基因之间存在强大的功能保守性。
