Sequence of a gene encoding beta-lactamase from Streptomyces cellulosae.

The nucleotide sequence of beta-lactamase (Bla)-encoding gene, bla, from Streptomyces cellulosae KCCS0127 was determined. The deduced amino acid sequence was very close to that of class-A Bla, especially those from Streptomyces species, but completely different from class-D Bla. This is contrary to the result expected from its substrate specificity and its property of binding blue dextran and NADP+.