阿尔茨海默病颞下回皮质神经原纤维缠结中的免疫反应模式

Immunoreactivity patterns in neurofibrillary tangles of the inferior temporal cortex in Alzheimer disease.

作者信息

Duong T, Gallagher K A

机构信息

Indiana University School of Medicine, Terre Haute Center for Medical Education, Indiana State University 47809.

出版信息

Mol Chem Neuropathol. 1994 Jun;22(2):105-22. doi: 10.1007/BF03160099.

DOI:10.1007/BF03160099

PMID:7916770

Abstract

The distributions of various immunohistochemical markers of neurofibrillary tangles (NFT) were compared to that of a normal nerve cell cytoskeletal marker, SMI32, in the inferior temporal cortex of Alzheimer brains and normal aged controls. NFT markers included antibodies to the microtubule-associated proteins tau, ubiquitin, or amyloid P component (AP). The results showed that, in our group of patients, the decrease of SMI32 immunoreactivity in the Alzheimer temporal cortex is paralleled by an increase in AP immunoreactivity in neurons and neurofibrillary tangles. This suggests that AP may play an important role in NFT formation or evolution in Alzheimer disease.

摘要

在阿尔茨海默病患者大脑的颞下回皮质以及正常老年对照中，比较了神经原纤维缠结（NFT）各种免疫组化标志物的分布与正常神经细胞细胞骨架标志物SMI32的分布。NFT标志物包括针对微管相关蛋白tau、泛素或淀粉样P成分（AP）的抗体。结果显示，在我们的患者组中，阿尔茨海默病颞叶皮质中SMI32免疫反应性的降低与神经元和神经原纤维缠结中AP免疫反应性的增加同时出现。这表明AP可能在阿尔茨海默病NFT的形成或演变中起重要作用。