Majmudar G, Nelson B R, Jensen T C, Johnson T M
Department of Dermatology, University of Michigan, Ann Arbor 48109.
Mol Carcinog. 1994 Sep;11(1):29-33. doi: 10.1002/mc.2940110106.
Nevoid basal cell carcinoma syndrome (NBCCS), an autosomal dominant disorder, is characterized by the development of numerous cutaneous basal cell carcinomas (BCCs). To better characterize this disorder, we examined the expression of matrix metalloproteinase-3 (MMP-3; also known as stromelysin-1) in BCC tumor specimens, adjacent normal skin, and fibroblasts isolated from the normal-appearing skin of NBCCS patients. Three of three BCC tumors obtained from NBCCS patients overexpressed MMP-3 mRNA. In contrast, only 25% of BCC specimens in patients without NBCCS demonstrated overexpression of MMP-3 mRNA. Moreover, fibroblasts isolated and cultured from all nine uninvolved skin specimens of NBCCS patients overexpressed MMP-3 mRNA. MMP-3 mRNA was not detected or was detected at very low levels in normal skin and fibroblast cultures isolated from normal skin in nonsyndrome patients.
痣样基底细胞癌综合征（NBCCS）是一种常染色体显性疾病，其特征是出现大量皮肤基底细胞癌（BCC）。为了更好地描述这种疾病，我们检测了BCC肿瘤标本、相邻正常皮肤以及从NBCCS患者外观正常皮肤中分离出的成纤维细胞中基质金属蛋白酶-3（MMP-3；也称为基质溶解素-1）的表达。从NBCCS患者获得的3个BCC肿瘤中有3个过表达MMP-3 mRNA。相比之下，无NBCCS患者的BCC标本中只有25%表现出MMP-3 mRNA过表达。此外，从NBCCS患者的所有9个未受累皮肤标本中分离并培养的成纤维细胞均过表达MMP-3 mRNA。在非综合征患者的正常皮肤和成纤维细胞培养物中未检测到MMP-3 mRNA或仅检测到极低水平的MMP-3 mRNA。
