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大鼠中蔗糖奖赏效应与下丘脑外侧刺激之间的竞争和总和

Competition and summation between rewarding effects of sucrose and lateral hypothalamic stimulation in the rat.

作者信息

Conover K L, Shizgal P

机构信息

Department of Psychology, Concordia University, Montreal, Quebec, Canada.

出版信息

Behav Neurosci. 1994 Jun;108(3):537-48. doi: 10.1037//0735-7044.108.3.537.

DOI:10.1037//0735-7044.108.3.537
PMID:7917048
Abstract

Rats were offered a forced choice between a train of brain stimulation that varied in strength from trial to trial and a fixed standard reward. This standard reward consisted of an intraoral sucrose infusion presented either alone or paired with an equipreferred train of brain stimulation. Postingestional effects were minimized by opening a gastric cannula. The presence of a sucrose standard led the subjects to forgo trains of brain stimulation for which they had responded when the sucrose was absent. The strength of the brain stimulation required to balance the compound reward exceeded the stimulation strength required to balance a reward consisting of sucrose alone. These results imply that the rewarding effects of brain stimulation and intraoral sucrose can be evaluated in a common system of measurement and combined.

摘要

让大鼠在每次试验强度不同的一系列脑刺激和固定标准奖励之间进行强制选择。这个标准奖励包括单独给予的口腔内蔗糖注入,或者与同等偏好的一系列脑刺激配对给予。通过打开胃插管将摄食后的影响降至最低。蔗糖标准的存在导致受试者放弃在没有蔗糖时他们会做出反应的一系列脑刺激。平衡复合奖励所需的脑刺激强度超过平衡仅由蔗糖组成的奖励所需的刺激强度。这些结果表明,脑刺激和口腔内蔗糖的奖励作用可以在一个共同的测量系统中进行评估并结合起来。

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