Balleine B, Dickinson A
Department of Experimental Psychology, University of Cambridge, England.
Behav Neurosci. 1994 Jun;108(3):590-605. doi: 10.1037//0735-7044.108.3.590.
In 4 experiments, the role of cholecystokinin (CCK) in the motivational control of instrumental performance in rats was assessed. Following instrumental training with food rewards, injections of CCK (either 2 micrograms/kg or 4 micrograms/kg) had no effect on instrumental performance in extinction, even when the opportunity was given to learn about the incentive value of the food outcome under CCK. These results contrasted markedly with the effects of shifts in food deprivation. Rewarded instrumental performance was, however, reduced by both doses of CCK, suggesting that CCK may mediate deprivation-related shifts in incentive value. Tests of this hypothesis found that the alimentary CCK antagonist devazepide (MK329) attenuated the devaluation of a food outcome produced by exposure to the outcome in a nondeprived state. These data are interpreted as suggesting that CCK may act as a satiety-specific incentive signal.
在4项实验中，评估了胆囊收缩素（CCK）在大鼠工具性表现的动机控制中的作用。在用食物奖励进行工具性训练后，注射CCK（2微克/千克或4微克/千克）对消退期的工具性表现没有影响，即使给予机会在CCK作用下了解食物结果的激励价值也是如此。这些结果与食物剥夺变化的影响形成了鲜明对比。然而，两种剂量的CCK都降低了有奖励的工具性表现，这表明CCK可能介导了与剥夺相关的激励价值变化。对这一假设的测试发现，消化性CCK拮抗剂地伐西匹（MK329）减弱了在非剥夺状态下接触食物结果所产生的食物结果贬值。这些数据被解释为表明CCK可能作为一种饱腹感特异性的激励信号。
