Meyer H G, Gatermann S
Institute for Medical Microbiology, Medical University of Lübeck, Germany.
APMIS. 1994 Jul;102(7):538-44.
Cell surface hydrophobicity may contribute to virulence in urinary tract pathogens. In this study we assess the influence of differential expression of the two major surface proteins (Ssp and the haemagglutinin) of Staphylococcus saprophyticus on cell surface hydrophobicity. The haemagglutinating strain CCM883, which does not produce Ssp, was hydrophobic regardless of the growth conditions. Strain 9325, which is non-haemagglutinating and produces Ssp, was hydrophobic only when grown in liquid media. Although these results suggest an association between the ability to express the haemagglutinin and the structure responsible for cell surface hydrophobicity, they refute any major role of Ssp and haemagglutinin in hydrophobicity. Treatment of bacteria with proteases reduces hydrophobicity, indicating that the structure mediating hydrophobicity is a protein.
细胞表面疏水性可能有助于尿路病原体的致病性。在本研究中，我们评估了腐生葡萄球菌两种主要表面蛋白（Ssp和血凝素）的差异表达对细胞表面疏水性的影响。不产生Ssp的血凝菌株CCM883，无论生长条件如何都具有疏水性。非血凝且产生Ssp的菌株9325仅在液体培养基中生长时才具有疏水性。尽管这些结果表明血凝素表达能力与负责细胞表面疏水性的结构之间存在关联，但它们反驳了Ssp和血凝素在疏水性方面的任何主要作用。用蛋白酶处理细菌会降低疏水性，这表明介导疏水性的结构是一种蛋白质。
