Khan S A, Pace J E, Cox M L, Gau D W, Cox S A, Hodkinson H M
Department of Geriatric Medicine, West Middlesex University Hospital, Isleworth.
Br J Clin Pract. 1994 Sep-Oct;48(5):240-2.
The incidence of climacteric symptoms was determined in 247 healthy premenopausal women in a community setting. These volunteers had been recruited to a longitudinal study of bone density. Of these subjects, 46 ceased to menstruate during the study, and in this subgroup symptoms were compared before and after cessation of menstruation. Only hot flushes increased after cessation of menstruation in the longitudinal study and showed age correlation in the cross-sectional study. Hot flushes thus emerged as a true menopausal symptom. Although evidence for this is weaker, cold sweats and suffocation seem likely to be genuinely menopausal. Breast discomfort and the four mood symptoms of irritability, excitability, depression and poor concentration improved after cessation of menstruation, and this study gives no support for their being part of the menopausal syndrome; it suggests that these symptoms are more likely to be related to menstruation than to the menopause.
在社区环境中，对247名健康的绝经前女性进行了更年期症状发生率的测定。这些志愿者被招募参加一项骨密度纵向研究。在这些受试者中，46人在研究期间停止月经，在这个亚组中，对月经停止前后的症状进行了比较。在纵向研究中，只有潮热在月经停止后增加，并且在横断面研究中显示出与年龄相关。因此，潮热成为一种真正的更年期症状。虽然对此的证据较弱，但盗汗和窒息似乎很可能是真正的更年期症状。乳房不适以及易怒、易激动、抑郁和注意力不集中这四种情绪症状在月经停止后有所改善，本研究不支持它们是更年期综合征的一部分；这表明这些症状更可能与月经有关，而不是与更年期有关。
