在芬兰，HLA - C第73位的丙氨酸与寻常型银屑病相关。
Alanine at position 73 of HLA-C is associated with psoriasis vulgaris in Finland.
作者信息
Ikäheimo I, Silvennoinen-Kassinen S, Karvonen J, Tiilikainen A
机构信息
Department of Medical Microbiology, University of Oulu, Finland.
出版信息
Br J Dermatol. 1994 Aug;131(2):257-9. doi: 10.1111/j.1365-2133.1994.tb08501.x.
Abstract
A close association was found between a specific sequence of HLA-C and psoriasis vulgaris in Finnish patients (chi 2 = 18.4, P = 1.78 x 10(-5)). This sequence codes for alanine at position 73 of the HLA-C molecule in the antigen binding cleft, and alanine may play a role in susceptibility to the disease.
摘要
在芬兰患者中发现寻常型银屑病与HLA - C的特定序列之间存在密切关联（卡方检验 = 18.4，P = 1.78×10⁻⁵）。该序列在抗原结合裂隙处的HLA - C分子第73位编码丙氨酸，丙氨酸可能在该疾病的易感性中起作用。
Zotero 插件