Abgrall J F, Berthou C, Sensebé L, Le Niger C, Escoffre M
Department of Haematology, University of Brest, School of Medicine, France.
Br J Haematol. 1993 Dec;85(4):803-4. doi: 10.1111/j.1365-2141.1993.tb03227.x.
In vitro megakaryocyte colony formation was studied in 25 patients with chronic idiopathic thrombocytopenic purpura (ITP), and compared to 16 controls. A significantly lower number of megakaryocyte progenitors (CFU-MK) was observed in patients (10.8 +/- 12.0 CFU-MK per 10(5) bone-marrow non-adherent mononuclear cells (NAMC), compared to controls (22.5 +/- 15.4 CFU-MK); P < 0.002. Only six patients had a normal number of CFU-MK. The number of CFU-MK was not correlated to initial platelet count (P = 0.35). These findings indicate that in vitro CFU-MK could be of interest in the diagnosis of chronic ITP, and also could be predictive for chronicity in patients with acute ITP.
对25例慢性特发性血小板减少性紫癜（ITP）患者进行了体外巨核细胞集落形成研究，并与16名对照者进行了比较。观察到患者的巨核细胞祖细胞（CFU-MK）数量显著减少（每10⁵个骨髓非贴壁单核细胞（NAMC）中有10.8±12.0个CFU-MK，而对照者为22.5±15.4个CFU-MK；P<0.002）。只有6例患者的CFU-MK数量正常。CFU-MK数量与初始血小板计数无关（P = 0.35）。这些发现表明，体外CFU-MK可能对慢性ITP的诊断有意义，也可能对急性ITP患者的慢性化有预测作用。
