Torchilin V P, Shtilman M I, Trubetskoy V S, Whiteman K, Milstein A M
Center for Imaging and Pharmaceutical Research, Massachusetts General Hospital-East, Charlestown 02129.
Biochim Biophys Acta. 1994 Oct 12;1195(1):181-4. doi: 10.1016/0005-2736(94)90025-6.
Newly synthesized amphiphilic polyacrylamide and poly(vinyl pyrrolidone), single terminus-modified with long-chain fatty acyl groups, are able to incorporate into the liposomal membrane, and similar to poly(ethylene glycol) prolong liposome circulation in vivo and decrease liposome accumulation in the liver. Protective efficacy of modified polymers increases with the increase in the length of acyl moiety and decreases for higher molecular weight polymers. The data on amphiphilic polymer-modified liposome biodistribution are presented.
新合成的两亲性聚丙烯酰胺和聚（乙烯基吡咯烷酮），其单端用长链脂肪酰基修饰，能够掺入脂质体膜中，并且与聚乙二醇类似，可在体内延长脂质体循环时间并减少脂质体在肝脏中的积累。修饰聚合物的保护效果随着酰基部分长度的增加而增强，而对于较高分子量的聚合物则降低。本文给出了两亲性聚合物修饰脂质体生物分布的数据。
