Cai Donglin, Gao Wendong, Li Zhelun, Zhang Yufeng, Xiao Lan, Xiao Yin
Centre for Biomedical Technologies, School of Mechanical, Medical & Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia.
State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Biomedicines. 2022 May 23;10(5):1203. doi: 10.3390/biomedicines10051203.
Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized.
巨噬细胞是参与各种炎症相关疾病的最重要的固有免疫细胞。因此，巨噬细胞相关的病理过程是疾病诊断和治疗的重要靶点。由于纳米颗粒（NPs）可被巨噬细胞优先摄取，NPs在特异性巨噬细胞靶向方面备受关注。在本综述中，介绍了NPs与免疫系统之间的相互作用，以帮助理解NPs在免疫细胞中的药代动力学和生物分布。对目前用于特异性巨噬细胞靶向的NPs修饰设计和策略进行了研究和总结。
