Theodorou V, Fioramonti J, Droy-Lefaix M T, Plique O, Buéno L
Department of Pharmacology, Institut National de la Recherche Agronomique, Toulouse, France.
Aliment Pharmacol Ther. 1994 Jun;8(3):295-9. doi: 10.1111/j.1365-2036.1994.tb00291.x.
Colonic transit time, faecal moisture and intestinal permeability were assessed in guinea-pigs sensitized intraperitoneally with cow's milk and challenged with an oral administration of beta-lactoglobulin. One group of animals was treated for 1 week with diosmectite (500 mg.kg/day) and another with placebo. A control group was not sensitized but treated with diosmectite.
In sensitized animals receiving placebo, challenge with beta-lactoglobulin induced a significant (P < 0.05) decrease in colonic transit time, and increases in faecal moisture and intestinal permeability. These changes were not observed in animals treated with diosmectite.
Diosmectite pre-treatment protects against allergic digestive disturbances induced by antigen administration in guinea-pigs sensitized to cow's milk.
对经腹腔注射牛奶致敏并用β-乳球蛋白口服激发的豚鼠，评估其结肠转运时间、粪便水分和肠道通透性。一组动物用蒙脱石（500毫克/千克/天）治疗1周，另一组用安慰剂治疗。对照组未致敏但用蒙脱石治疗。
接受安慰剂的致敏动物，用β-乳球蛋白激发后，结肠转运时间显著缩短（P < 0.05），粪便水分和肠道通透性增加。在用蒙脱石治疗的动物中未观察到这些变化。
蒙脱石预处理可预防对牛奶致敏的豚鼠因抗原给药引起的过敏性消化紊乱。
