Theodorou V, Fioramonti J, Bueno L
Department of Pharmacology, INRA, Toulouse, France.
Life Sci. 1993;53(9):733-8. doi: 10.1016/0024-3205(93)90250-7.
Recombinant interleukin-1 receptor antagonist protein (rlRAP, 0.5 mg/kg) administered intraperitoneally in guinea pigs one hour before primary and booster parenteral sensitization (1 ml) by cow milk, led to a reduced immunoglobulin E (IgE) production, as displayed by a passive cutaneous anaphylaxis test. rlRAP administered intraperitoneally in sensitized guinea pigs at 0.5 mg/kg 10 min before challenge administration (beta-lactoglobulin, 100 mg per os), also prevents the colonic motor and secretory changes induced by intestinal anaphylaxis. These results suggest the involvement of interleukin-1 in food allergy and evidence a double protective role for rlRAP in food hypersensitivity.
在豚鼠通过牛奶进行初次和加强肠胃外致敏（1毫升）前一小时，腹腔注射重组白细胞介素-1受体拮抗剂蛋白（rlRAP，0.5毫克/千克），如被动皮肤过敏试验所示，可导致免疫球蛋白E（IgE）产生减少。在致敏豚鼠接受激发给药（β-乳球蛋白，口服100毫克）前10分钟腹腔注射0.5毫克/千克的rlRAP，也可预防肠道过敏引起的结肠运动和分泌变化。这些结果表明白细胞介素-1参与食物过敏，并证明rlRAP在食物超敏反应中具有双重保护作用。
