Ashraf W, Lof J, Jin G, Quigley E M
Section of Digestive Diseases and Nutrition, University of Nebraska Medical Center, Omaha 68198-2000.
Aliment Pharmacol Ther. 1994 Jun;8(3):329-36. doi: 10.1111/j.1365-2036.1994.tb00296.x.
BACKGROUND/AIM: To define the possible contribution of altered small intestinal motor activity to side-effects of bulking fibres, we sought to compare the relative effects of intraduodenal and intracolonic administration of the bulking fibre psyllium and the anthraquinone laxative senna on canine small intestinal motor activity.
Motor activity was recorded by serosal strain gauges implanted along the small intestine in 6 dogs. In random order, the motor responses to the instillation of psyllium (in doses of 5 or 10 g), senna (10 mg/kg) or appropriate vehicle (200 ml water infusion or saline 5 ml bolus) into either the proximal duodenum or proximal colon were assessed.
The intra-duodenal administration of psyllium in either dose consistently induced a prolonged burst of 'clustered' contractions; in contrast, clusters were infrequent and of short duration following instillation of either vehicle or senna (P < 0.05). Intraduodenal instillation of psyllium inhibited migrating motor complex (MMC) migration and consistently delayed the onset of the next MMC cycle; a similar inhibition occurred with vehicle, however. Neither senna nor its vehicle inhibited MMC migration. None of these agents had any effect on small intestinal motor activity when instilled directly into the colon.
Psyllium administered directly into the duodenum inhibits MMC activity and consistently induces 'clustered' contractions. Whilst the MMC-inhibitory effect appears to be a non-specific volume-related phenomenon, the induction of clusters is independent of volume or laxation. These motor effects of psyllium may contribute to the gastrointestinal symptomatology related to such agents and could be avoided by the preferential release of psyllium in the colon.
背景/目的：为了确定小肠运动活动改变对容积性纤维副作用的可能影响，我们试图比较容积性纤维车前草和蒽醌类泻药番泻叶十二指肠内给药和结肠内给药对犬小肠运动活动的相对影响。
通过植入6只犬小肠的浆膜应变仪记录运动活动。以随机顺序评估向十二指肠近端或结肠近端注入车前草（剂量为5或10 g）、番泻叶（10 mg/kg）或适当载体（200 ml静脉输注水或5 ml生理盐水推注）后的运动反应。
两种剂量的车前草十二指肠内给药均持续诱导“成簇”收缩的长时间爆发；相比之下，注入载体或番泻叶后成簇收缩很少见且持续时间短（P<0.05）。十二指肠内注入车前草抑制移行性运动复合波（MMC）的移行，并持续延迟下一个MMC周期的开始；然而，载体注入也出现类似的抑制作用。番泻叶及其载体均未抑制MMC移行。这些药物直接注入结肠时对小肠运动活动均无影响。
直接注入十二指肠的车前草抑制MMC活动并持续诱导“成簇”收缩。虽然MMC抑制作用似乎是一种非特异性的容量相关现象，但成簇收缩的诱导与容量或通便作用无关。车前草的这些运动效应可能导致与此类药物相关的胃肠道症状，通过使车前草在结肠中优先释放可避免这些症状。
