Noguchi M, Kitagawa H, Kinoshita K, Thomas M, Miyazaki I, Saito Y, Mizukami Y, Nonomura A, Michigishi T, Nakamura S
Operation Center, Kanazawa University Hospital, School of Medicine, Japan.
Surg Today. 1994;24(6):512-7. doi: 10.1007/BF01884570.
The p53 expression in invasive breast cancers from 106 patients was correlated with clinicopathological variables to ascertain its usefulness for estimating prognosis. The p53 expression was significantly associated with the number of axillary lymph node metastases and the presence of internal mammary lymph node metastases; however, it was not associated with age, menopausal status, histologic type, or tumor size. Although p53 expression was a significant prognostic factor according to univariate analysis, it did not appear to be an independent prognostic factor according to multivariate analysis. Thus, the prognostic power of p53 expression is likely to be weak and therefore probably of limited clinical value. Nevertheless, the number of patients in our study was small, and we believe that an investigation of a larger series of patients is indicated.
对106例浸润性乳腺癌患者的p53表达与临床病理变量进行相关性分析，以确定其在评估预后方面的作用。p53表达与腋窝淋巴结转移数目及内乳淋巴结转移的存在显著相关；然而，它与年龄、绝经状态、组织学类型或肿瘤大小无关。虽然根据单因素分析p53表达是一个显著的预后因素，但根据多因素分析它似乎不是一个独立的预后因素。因此，p53表达的预后能力可能较弱，临床价值可能有限。尽管如此，我们研究中的患者数量较少，我们认为有必要对更多患者进行研究。
