Noguchi M, Kitagawa H, Kinoshita K, Miyazaki I, Saito Y, Mizukami Y
KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,DEPT RADIOL,KANAZAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,PATHOL SECT,KANAZAWA 920,JAPAN.
Int J Oncol. 1993 Apr;2(4):587-91. doi: 10.3892/ijo.2.4.587.
We analyzed associations among p53 and c-erbB-2 expression and clinicopathologic variables and, then ascertained whether p53 and/or c-erbB-2 expression would be useful for estimating prognosis in 105 breast cancer patients. There was no significant association between p53 and c-erbB-2 expression, but the combination of p53 and c-erbB-2 expression was significantly associated with axillary lymph node metastases. Although both p53 and c-erbB-2 expressions were significant prognostic factors by univariate analysis, they did not appear to be independent prognostic factors by multivariate analysis in which nodal status was introduced using the Cox model. When nodal status was excluded, however, p53 and c-erbB-2 expression each had independent prognostic value.
我们分析了p53和c-erbB-2表达与临床病理变量之间的关联，然后确定p53和/或c-erbB-2表达是否有助于评估105例乳腺癌患者的预后。p53和c-erbB-2表达之间无显著关联，但p53和c-erbB-2表达的联合与腋窝淋巴结转移显著相关。虽然单因素分析显示p53和c-erbB-2表达均为显著的预后因素，但在使用Cox模型引入淋巴结状态的多因素分析中，它们似乎并非独立的预后因素。然而，当排除淋巴结状态时，p53和c-erbB-2表达各自具有独立的预后价值。
