Mueller-Eckhardt G
Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität, Giessen.
Infusionsther Transfusionsmed. 1994 Jun;21(3):192-7.
The discovery of the HLA system as well as the progress of knowledge over several decades were based on serological methods. Today, methods of molecular biology tend to replace serological tests for HLA typing, particularly for class II alleles. However, HLA serology is still indispensable in all domains where HLA antibodies play a role. In this contribution, classical and more recently developed methods of HLA serology are described, and problems and solutions concerning the interpretation of results are discussed.
HLA系统的发现以及几十年来知识的进步都基于血清学方法。如今，分子生物学方法倾向于取代用于HLA分型的血清学检测，尤其是对于II类等位基因。然而，在HLA抗体发挥作用的所有领域，HLA血清学仍然不可或缺。在本论文中，描述了HLA血清学的经典方法和最近开发的方法，并讨论了结果解读方面的问题及解决方案。
