Silva A J, Giese K P
Cold Spring Harbor Laboratory, New York 11724.
Curr Opin Neurobiol. 1994 Jun;4(3):413-20. doi: 10.1016/0959-4388(94)90104-x.
Even though the synthesis of new proteins is thought to be essential for long-term changes in synaptic plasticity, as well as for long-term memory, little is known about the identity of the required proteins. The hunt for these molecules is under way, however, and in the past year several groups of researchers have entered this fascinating search by introducing new approaches that have lead to the identification of several potential candidates, amongst which are trophic factors, kinases, ion channels, and proteases. The results will have much to say not only about the nature of memory, but also about the mechanisms of learning.
尽管新蛋白质的合成被认为对于突触可塑性的长期变化以及长期记忆至关重要，但对于所需蛋白质的具体身份却知之甚少。不过，对这些分子的搜寻正在进行中，在过去的一年里，几组研究人员通过引入新方法进入了这场引人入胜的探索，这些新方法已导致鉴定出几个潜在的候选分子，其中包括营养因子、激酶、离子通道和蛋白酶。这些结果不仅将对记忆的本质有很多可说之处，而且对学习机制也有很多可说之处。
