Abel T, Martin K C, Bartsch D, Kandel E R
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
Science. 1998 Jan 16;279(5349):338-41. doi: 10.1126/science.279.5349.338.
Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory storage. Molecular studies of gene expression during long-lasting synaptic plasticity related to memory storage initially focused on the identification of positive regulators. More recent work has revealed that the establishment of long-lasting synaptic plasticity and long-term memory also requires the removal of inhibitory constraints. By analogy to tumor suppressor genes, which restrain cell proliferation, we propose that these inhibitory constraints of memory storage, which restrain synapse growth, be termed memory suppressor genes.
突触可塑性，即神经元根据活动和经验改变其突触连接强度的能力，被认为在记忆存储中起着关键作用。与记忆存储相关的持久突触可塑性过程中基因表达的分子研究最初集中于鉴定正向调节因子。最近的研究表明，持久突触可塑性和长期记忆的形成还需要消除抑制性限制。类似于抑制细胞增殖的肿瘤抑制基因，我们提出这些抑制记忆存储（抑制突触生长）的抑制性限制可被称为记忆抑制基因。
