Serban M G, Tănăseanu S
C. Davilla University of Medicine and Pharmacy, Department of Physiopathology, Bucharest, Romania.
Rom J Intern Med. 1994 Apr-Jun;32(2):137-42.
The effect of treatment with prednisone on lipid peroxidation and on lipid metabolism generally and the effect of vitamin E on plasma lipid peroxidation were studied in a group of patients with autoimmune systemic vasculitides. Vitamin E total plasma antioxidant capacity was determined to ascertain the antioxidant efficiency of vitamin E. Treatment with prednisone was found to induce disturbances of the lipid metabolism at the level of total cholesterol and of triglycerides. The increased values of the LDL/HDL ratio showed an increased risk of vascular disturbance in the patients investigated. The high level of lipid peroxides associated with a reduced activity of the endogenous antioxidant system was found to be uninfluenced by treatment with prednisone. Treatment with vitamin E reduced the process of lipid peroxidation but the endogenous deficiency of the antioxidant capacity prevented it to resume its normal values. In spite of the antiinflammatory and antioxidant treatment the high level of lipid peroxides might induce a self-maintained chronic process which, in time, might lead to the aggravation of the degenerative vascular changes.
在一组自身免疫性系统性血管炎患者中，研究了泼尼松治疗对脂质过氧化及一般脂质代谢的影响，以及维生素E对血浆脂质过氧化的影响。测定了维生素E的总血浆抗氧化能力，以确定维生素E的抗氧化效率。发现泼尼松治疗会在总胆固醇和甘油三酯水平上引发脂质代谢紊乱。低密度脂蛋白/高密度脂蛋白比值升高表明所研究患者发生血管紊乱的风险增加。发现与内源性抗氧化系统活性降低相关的高脂质过氧化物水平不受泼尼松治疗的影响。维生素E治疗可减少脂质过氧化过程，但抗氧化能力的内源性缺乏使其无法恢复到正常水平。尽管进行了抗炎和抗氧化治疗，但高脂质过氧化物水平可能会引发一个自我维持的慢性过程，随着时间的推移，可能会导致退行性血管变化加重。
