Furlong A J, al-Nakib L, Knox W F, Parry A, Bundred N J
Department of Surgery, University Hospital of South Manchester, United Kingdom.
J Am Coll Surg. 1994 Oct;179(4):417-20.
Cigarette smoking has been implicated in the etiology of periductal mastitis. The mechanism by which it causes inflammation around the mammary ducts is unknown.
Inflammation and dilatation of the mammary ducts were compared in two groups of women with proven histologic diagnoses of periductal mastitis (PDM, n = 133) and intraductal papilloma (IDP, n = 98) over an eight year period. This study was done to determine if the number of cigarettes smoked correlated with the amount of periductal inflammation seen in PDM. Duct dilatation, periductal inflammation, and squamous metaplasia were assessed objectively by two pathologists without knowledge of the clinical parameters.
Women with PDM were significantly more likely to be smokers than women with IDP (p < 0.001). Women with severe periductal inflammation were more likely to be younger (p < 0.05) whereas those with duct dilatation were more likely to be older (p < 0.02). Women with PDM who were heavy smokers (more than ten cigarettes per day) had more periductal inflammation (p = 0.0006) and squamous metaplasia of the lactiferous ducts (p < 0.02) compared with light or nonsmokers. Duct dilatation did not correlate with smoking habits.
Cigarette smoking appears to be an important etiologic factor in periductal mastitis and appears to have direct toxic effects on the mammary ducts.
吸烟与导管周围乳腺炎的病因有关。其导致乳腺导管周围炎症的机制尚不清楚。
在八年时间里，对两组经组织学确诊为导管周围乳腺炎（PDM，n = 133）和导管内乳头状瘤（IDP，n = 98）的女性的乳腺导管炎症和扩张情况进行了比较。本研究旨在确定吸烟数量是否与PDM中所见的导管周围炎症程度相关。两名病理学家在不了解临床参数的情况下，对导管扩张、导管周围炎症和鳞状化生进行了客观评估。
PDM女性比IDP女性更有可能是吸烟者（p < 0.001）。导管周围炎症严重的女性更年轻（p < 0.05），而有导管扩张的女性年龄更大（p < 0.02）。与轻度吸烟者或不吸烟者相比，重度吸烟（每天超过十支）的PDM女性有更多的导管周围炎症（p = 0.0006）和输乳管鳞状化生（p < 0.02）。导管扩张与吸烟习惯无关。
吸烟似乎是导管周围乳腺炎的一个重要病因，并且似乎对乳腺导管有直接毒性作用。
