Dixon J M, Ravisekar O, Chetty U, Anderson T J
University Department of Surgery, Edinburgh Royal Infirmary, UK.
Br J Surg. 1996 Jun;83(6):820-2. doi: 10.1002/bjs.1800830630.
A prospective study of 14,225 patients has been undertaken to determine the inter-relationship between periductal mastitis and duct ectasia and to establish whether there is an association between smoking and either of these two conditions. Periductal mastitis affected women at a younger age than did duct ectasia. Of 139 patients with the clinical syndrome of periductal mastitis, 97 (70 per cent) had a past history of previous periductal mastitis, compared with only one (1 per cent) of 186 patients with the clinical syndrome of duct ectasia (P < 0.0001). There was a significant excess of smokers in patients with clinically (124 (89 per cent) of 139) and pathologically (71 (91 per cent) of 78) diagnosed periductal mastitis compared with age-matched controls (both P < 0.001), but there was no such excess in those with clinically (52 (28 per cent) of 186) or pathologically (15 (23 per cent) of 64) diagnosed duct ectasia. These data suggest that periductal mastitis and duct ectasia are separate conditions which affect different age groups, have different aetiologies, and should now be considered as separate entities.
对14225名患者进行了一项前瞻性研究，以确定导管周围乳腺炎与导管扩张之间的相互关系，并确定吸烟与这两种病症中的任何一种是否存在关联。导管周围乳腺炎患者的年龄比导管扩张患者小。在139例有导管周围乳腺炎临床综合征的患者中，97例（70%）有既往导管周围乳腺炎病史，而在186例有导管扩张临床综合征的患者中只有1例（1%）有既往病史（P<0.0001）。与年龄匹配的对照组相比，临床诊断（139例中的124例（89%））和病理诊断（78例中的71例（91%））为导管周围乳腺炎的患者中吸烟者显著过多（均P<0.001），但临床诊断（186例中的52例（28%））或病理诊断（64例中的15例（23%））为导管扩张的患者中没有这种过多情况。这些数据表明，导管周围乳腺炎和导管扩张是不同的病症，影响不同年龄组，病因不同，现在应被视为不同的实体。
